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  • Title: Single-dose prophylaxis in gynaecological surgery: amoxycillin/clavulanic acid versus the combination of cefuroxim and metronidazole in a randomized prospective comparison.
    Author: Friese S, Pricker GJ, Willems FT, Loriaux SM.
    Journal: Eur J Obstet Gynecol Reprod Biol; 1988 Apr; 27(4):313-7. PubMed ID: 3384164.
    Abstract:
    A prospective randomized study was conducted comparing a single 2.2 g preoperative dose amoxycillin/clavulanic acid with a regimen of 1.5 g cefuroxim combined with 0.5 g metronidazole. Two hundred and fifty-one women were evaluated in this comparative study. The febrile morbidity, the incidence of urinary tract infections and the hospital stay were similar in both regimens. A single preoperative dose of amoxycillin/clavulanic acid was as effective as a combined regimen of cefuroxim and metronidazole and less expensive.
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