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  • Title: Classification Criteria for Tubulointerstitial Nephritis With Uveitis Syndrome.
    Author: Standardization of Uveitis Nomenclature (SUN) Working Group.
    Journal: Am J Ophthalmol; 2021 Aug; 228():255-261. PubMed ID: 33845023.
    Abstract:
    PURPOSE: To determine classification criteria for tubulointerstitial nephritis with uveitis (TINU). DESIGN: Machine learning of cases with TINU and 8 other anterior uveitides. METHODS: Cases of anterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used on the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the anterior uveitides. The resulting criteria were evaluated on the validation set. RESULTS: One thousand eighty-three cases of anterior uveitides, including 94 cases of TINU, were evaluated by machine learning. The overall accuracy for anterior uveitides was 97.5% in the training set and 96.7% in the validation set (95% confidence interval 92.4, 98.6). Key criteria for TINU included anterior chamber inflammation and evidence of tubulointerstitial nephritis with either (1) a positive renal biopsy or (2) evidence of nephritis (elevated serum creatinine and/or abnormal urine analysis) and an elevated urine β-2 microglobulin. The misclassification rates for TINU were 1.2% in the training set and 0% in the validation set. CONCLUSIONS: The criteria for TINU had a low misclassification rate and seemed to perform well enough for use in clinical and translational research.
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