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  • Title: Hypersensitivity of the human gonadotrophs to the repeated administration of small doses of LH-RH.
    Author: Faure N, Olivier GC.
    Journal: Horm Res; 1978; 9(1):12-21. PubMed ID: 338460.
    Abstract:
    The functional capacity of the gonadotrophs was assessed by repeated stimulation with small doses of LH-RH (5 microgram intravenously at 2-hour intervals for 3 injections) in normal women during the early and late follicular phases of the menstrual cycle. The results were compared to those obtained when a single dose (100 microgram) of the neurohormone was administered. During the early follicular phase, the release of LH and FSH remained about equal after the 3 successive injections of the small and after the large dose of LH-RH. During the late follicular phase, the release of LH and fsh increased progressively after the repeated administration of the 5 microgram of the neurohormone while the large dose induced a more pronounced and a more sustained pituitary response. This hypersensitivity of the gonadotrophs is observed when the E2 concentrations are higher than in the early follicular phase of the menstrual cycle. 5 normal women (20-30 years of age) received luteinizing hormone-releasing hormone (LH-RH) in 5 mcg doses for a total of 3 injections on Day 5 of their menstrual cycle, 8 other women received the same treatment between Days 10-14 of a normal cycle, and the results obtained compared with those observed when 100 mcg LH-RH was given during the early follicular and midluteal phase, in order to examine the functional capacity of the gonadotrophs. LH, follicle stimulating hormone (FSH), and estradiol were measured by radioimmunoassay. During the follicular phase of the menstrual cycle small repeated doses of LH-RH cause maximal LH concentrations after the 2nd and 3rd injections. The area under the curve was very similar to that obtained after a single dose of LH-RH. When this experiment was repeated in the late follicular phase, the 1st dose produced an increase in LH 3 times basal values. The 2nd and 3rd injections produced increases which were statistically significant from the 1st (p .05). The LH pituitary response to 100 mcg during the luteal phase was 4 times higher and more sustained than the 1st injection at the lower dose but very similar to levels obtained after the 3rd injection. Hypersensitivity is observed in the gonadotrophs when estradiol levels are higher than in the early follicular phase of the cycle.
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