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  • Title: Hemoglobin Brest [beta 127 (H5)Gln----Lys] a new unstable human hemoglobin variant located at the alpha 1 beta 1 interface with specific electrophoretic behavior.
    Author: Baudin-Chich V, Wajcman H, Gombaud-Saintonge G, Arous N, Riou J, Brière J, Galacteros F.
    Journal: Hemoglobin; 1988; 12(2):179-88. PubMed ID: 3384710.
    Abstract:
    Hb Brest [beta 127 (H5)Gln----Lys] is a new unstable variant located at the alpha 1 beta 1 interface at the same position as Hb Complutense [beta 127(H5)Gln----Glu]. In each of these, the substitution produces a distinct alteration in charge, yet both variants move with Hb A in conventional electrophoresis. This peculiar electrophoretical behavior may be due to the molecular position of the modified residue, which is deeply buried inside the tetramer.
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