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  • Title: Respiratory and metabolic responses of fetal and neonatal perfused livers to catecholamines and anoxia.
    Author: Kaneoka T, Taguchi S, Shimizu H, Shirakawa K.
    Journal: Nihon Sanka Fujinka Gakkai Zasshi; 1988 May; 40(5):627-34. PubMed ID: 3385281.
    Abstract:
    The effects of catecholamine and anoxia on the respiratory and metabolic function of developing livers were studied. The characteristic feature of the fetal liver was catecholamine induced glycolysis, although that of the neonatal liver was gluconeogenesis. Infusion of lactate and pyruvate caused a reduction in NAD in the fetus and adult, and NAD oxidation in the newborn. The fetal liver demonstrated marked tolerance of anoxic load, but the tolerance was rapidly lost after birth. The metabolic response to catecholamine may be mediated by the alpha-adrenergic receptor rather than the beta-receptor.
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