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  • Title: Transmethylation hypothesis of schizophrenia: methionine and nicotinic acid.
    Author: Nestoros JN, Ban TA, Lehmann HE.
    Journal: Int Pharmacopsychiatry; 1977; 12(4):215-46. PubMed ID: 338534.
    Abstract:
    The transmethylation hypothesis of schizophrenia was reviewed with considerations that large doses of methionine when combined with a monoamine oxidase inhibitor lead to exacerbation of psychotic symptoms in a significant percentage of chronic schizophrenic patients. It was noted that nicotinic acid in the dosage of 3,000 mg/day can neither prevent nor counteract the psychopathology thus induced.
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