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  • Title: [Assessment of different variants of hyperfractionated irradiation in cancer of the naso- and oropharynx and of the oral mucosa].
    Author: Aliev BM, Chuprik-Malinovskaia TP, Aleknavichius EE.
    Journal: Med Radiol (Mosk); 1988 Jun; 33(6):37-41. PubMed ID: 3386429.
    Abstract:
    The authors presented comparative analysis of the results of hyperfractionated gamma-irradiation of 75 patients with locally advanced head and neck tumors (stages II-IV) in various types of daily dose fractionation. 33 patients of the 1st group received radiotherapy at a dose of 1.2 Gy twice a day at a 6h-interval up to a total dose of 70-75 Gy, 23 patients of the 2nd group were irradiated at a dose of 1 Gy 3 times a day at a 3h-interval up to a total dose of 60-65 Gy, 19 patients of the 3rd group were irradiated at a dose of 1 Gy 5 times a day up to a total dose of 60 Gy. The authors have shown the prospects of hyperfractionated irradiation with two- and threefold daily dose fractionation in which complete tumor resorption was 94-95%, the 2-year survival was 60.6 +/- 7 and 75%, respectively without signs of late complications.
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