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  • Title: Cytosolic free calcium levels increase with age in rat brain synaptosomes.
    Author: Martinez A, Vitórica J, Satrústegui J.
    Journal: Neurosci Lett; 1988 Jun 07; 88(3):336-42. PubMed ID: 3386880.
    Abstract:
    Calcium homeostasis in synaptosomes is altered during ageing. The cytosolic free calcium concentration, [Ca2+]i was determined in synaptosomes and crude synaptosomal fractions from 3- and 24-month-old rats with the fluorescent indicator quin-2. The [Ca2+]i were around two times higher in 24-month-old rats than in adults, both under resting conditions and after K depolarization. This difference was still observed after incubation with an endogenous heavy metal chelator. To avoid the calcium buffering effect of quin-2, [Ca2+]i values were determined with the use of a null-point method and with fura-2. These methods confirmed the increase in [Ca2+]i with age in synaptosomes. The increase in [Ca2+]i in nerve endings may be pathologically important in brain ageing.
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