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  • Title: [Etiology and pathogenesis of synovitis villonodosa pigmentosa].
    Author: Imhoff A, Schreiber A.
    Journal: Orthopade; 1988 Apr; 17(2):223-32. PubMed ID: 3387098.
    Abstract:
    Articular pigmented villonodular synovitis is a benign synovial disease of unknown etiology. It is a proliferative disorder of the synovium that can involve the joints, tendon sheaths, and bursae. There is a predilection for involvement of the lower extremities, particularly the knees. There are two histologically similar lesions of pigmented villonodular synovitis: "nodular" and "diffuse" pigmented villonodular tenosynovitis. The typical clinical course consists of progressive and painful swelling of the involved joint. Cystic erosions without sclerosis and invasion of adjacent bone from intra-articular synovial lesions are the typical roentgenographic manifestations. The surgical treatment of the lesions is discussed. A review of the literature is given and our own material on 47 patients is presented to illustrate the different features of the disease.
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