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  • Title: Antidotal effects of deferrioxamine in experimental liver injury--role of lipid peroxidation.
    Author: Siegers CP, Steffen B, Younes M.
    Journal: Pharmacol Res Commun; 1988 Apr; 20(4):337-43. PubMed ID: 3387462.
    Abstract:
    Pretreatment with deferrioxamine (DFO, 125-500 mg/kg i.p.) protected male mice against CCl4- or CBrCl3-induced hepatotoxicity which is closely related to an inhibition of iron-dependent lipid peroxidation monitored by ethane exhalation. For allyl alcohol, 1,1-dichloroethylene, dimethylnitrosamine, thioacetamide, bromobenzene and paracetamol no hepatoprotection was achieved with DFO indicating that lipid peroxidation is not involved as a primary mechanism of toxicity. In the case of bromobenzene a marked in vivo lipid peroxidation was observed, which was unaffected by DFO and appears therefore to be iron-dependent.
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