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  • Title: Ultrasound-Enhanced Self-Exciting Photodynamic Therapy Based on Hypocrellin B.
    Author: Ding Y, Liu W, Wu J, Zheng X, Ge J, Ren H, Zhang W, Lee CS, Wang P.
    Journal: Chem Asian J; 2021 May 17; 16(10):1221-1224. PubMed ID: 33881805.
    Abstract:
    Peroxalate CL as an energy source to excite photosensitizers has attracted tremendous attention in photodynamic therapy (PDT). In this work, peroxyoxalate CPPO and hypocrellin B (HB)-based nanoparticles (CBNPs) for ultrasound (US)-enhanced self-exciting PDT were designed and prepared. CBNPs showed an excellent therapeutic effect against cancer cells with the assistance of US. This US-enhanced-chemiluminescence system avoids the dependence on external light and provides an example for inspiring more effective and precise strategies for cancer treatment.
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