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  • Title: Use of a solid phase red blood cell adherence method for pretransfusion platelet compatibility testing.
    Author: Rachel JM, Summers TC, Sinor LT, Plapp FV.
    Journal: Am J Clin Pathol; 1988 Jul; 90(1):63-8. PubMed ID: 3389344.
    Abstract:
    A solid phase red blood cell adherence method has been used for platelet antibody detection and crossmatching for refractory platelet recipients. Patient sera were first screened for HLA or platelet-specific antibodies, then crossmatched with potential apheresis platelet donors. The overall correlation of platelet crossmatch results with transfusion outcome was 97% in patients with no evidence of nonimmune platelet destruction. The solid phase red blood cell adherence method provided a feasible and effective alternative to HLA matching as a means of donor selection for refractory platelet recipients. The speed and simplicity of this method may allow most hospital laboratories to perform platelet antibody screening before routine platelet transfusions.
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