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  • Title: Reductions in acetylcholine and nicotine binding in several degenerative diseases.
    Author: Whitehouse PJ, Martino AM, Marcus KA, Zweig RM, Singer HS, Price DL, Kellar KJ.
    Journal: Arch Neurol; 1988 Jul; 45(7):722-4. PubMed ID: 3390025.
    Abstract:
    Alzheimer's disease, Parkinson's disease, and progressive supranuclear palsy are all characterized by loss of neurons in the basal forebrain cholinergic system and by associated reductions in cortical presynaptic cholinergic markers, such as choline acetyltransferase. In this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding.
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