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  • Title: Biomimetic Molecular Clamp Nanopores for Simultaneous Quantifications of NAD+ and NADH.
    Author: Liu X, Feng W, Yao F, Zhang J, Ayesha R, Chen T, Shi X, Qiao X, Ma L, Yu S, Kang XF.
    Journal: Anal Chem; 2021 May 11; 93(18):7118-7124. PubMed ID: 33905222.
    Abstract:
    NADH/NAD+ is pivotal to fundamental biochemistry research and molecular diagnosis, but recognition and detection for them are a big challenge at the single-molecule level. Inspired by the biological system, here, we designed and synthesized a biomimetic NAD+/NADH molecular clamp (MC), octakis-(6-amino-6-deoxy)-γ-cyclomaltooctaose, and harbored in the engineered α-HL(M113R)7 nanopore, forming a novel single-molecule biosensor. The single-molecule measurement possesses high selectivity and a high signal-to-noise ratio, allowing to simultaneously recognize and detect for sensing NADH/NAD+ and their transformations.
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