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  • Title: Four new phenanthrene derivatives from Bulbophyllum retusiusculum.
    Author: Fang YS, Yang MH, Wang JP, Fu H, Cai L, Ding ZT.
    Journal: Fitoterapia; 2021 Jul; 152():104910. PubMed ID: 33905817.
    Abstract:
    Three new dihydrophenanthrenes, retusiusine D (1), retusiusine E (2), retusiusine F (3), and a new phenanthrene retusiusine G (4), together with two known dihydrophenanthrenes 4,7-dihydroxy-2,3-methylenedioxy-9,10-dihydrophenanthrene (5) and epemeranthol-A (6) were isolated from the tubers of Bulbophyllum retusiusculum. Their structures were established on the basis of extensive spectroscopic analyses. Compounds 1 and 2 exhibited potent cytotoxic activities against SMMC-7721 and weak cytotoxic activities against HL-60. Compound 4 showed moderate cytotoxic activity against SMMC-7721 and MCF-7.
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