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  • Title: [Effect of modifiers of microsomal enzymes on the enzymatic denitrosation of dialkyl-N-nitrosamines].
    Author: Arshinov VIu, Shuliakovskaia TS.
    Journal: Eksp Onkol; 1988; 10(2):20-2. PubMed ID: 3391120.
    Abstract:
    The antioxidant butyl-hydroxytoluene has been shown to increase denitrosation of some dialkyl-N-nitrosamines by the liver microsomes of different lines of rats and to protect against diethyl-N-nitrosamine toxicity. 3-Methylcholanthrene, while decreasing denitrosation of diethyl-N-nitrosamine, increased its toxic effect. This data suggested that enzymatic denitrosation is an effective pathway for the inactivation of dialkyl-N-nitrosamines.
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