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  • Title: A simple strategy for constructing PET fluorescent probe and its application in hypochlorite detection.
    Author: Zhang X, Zhang F, Yang B, Liu B.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2021 Sep 05; 258():119827. PubMed ID: 33915338.
    Abstract:
    It is great meaningful to develop a fast and efficient method for detecting hypochlorite (ClO-) owing to its importance in the immune system. In this work, we proposed a strategy to construct fluorescent probes for ClO- based on photoinduced electron transfer (PET) mechanism. According to the strategy, we developed four fluorescent probes named TPA-NO2, TPA-2NO2, TPB-NO2 and TPB-2NO2, and studied their detecting performances for hypochlorite. Among them, TPB-NO2 displayed the most obvious fluorescence changes towards ClO- with a rapid response (<90 s). The detection limit was calculated to be 0.36 μM. Moreover, probe TPB-NO2 was successfully used to detect ClO- in living cells and zebrafish. These results demonstrated the feasibility of our strategy and provided a guidance for developing more excellent probes in the future.
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