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  • Title: Treatment of bovine lymphosarcoma with L-asparaginase.
    Author: Masterson MA, Hull BL, Vollmer LA.
    Journal: J Am Vet Med Assoc; 1988 May 01; 192(9):1301-2. PubMed ID: 3391857.
    Abstract:
    L-asparaginase was used to treat a 4-year-old Holstein cow with lymphosarcoma that involved the spinal cord, subiliac lymph nodes, and retrobulbar space. The cow received 60,000 IU of L-asparaginase IV for a total of 4 treatments. After each treatment, the cow's condition improved, characterized by decreased weakness, decreased ataxia, a reduction in size of the left subiliac lymph node, and decreased exophthalmos. Side effects were not observed. The cow was kept alive for 57 days. This treatment offers a way of salvaging the genetic potential of valuable cows and bulls.
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