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  • Title: The effects of prostacyclin (PGI2) on tissues which detect prostaglandins (PG'S).
    Author: Omini C, Moncada S, Vane JR.
    Journal: Prostaglandins; 1977 Oct; 14(4):625-32. PubMed ID: 339280.
    Abstract:
    The effects of prostacyclin (PGI2) and its stable metabolite 6-oxo-PGF1alpha on various bioassay tissues are compared with those of PGE2 and PGF2alpha, using the cascade superfusion method. On vascular smooth muscle, PGI2 caused relaxation of all tissues tested except the rabbit aorta. PGE2 relaxed rabbit coeliac and mesenteric artery but contracted bovine coronary artery and had no effect on rabbit aorta. 6-oxo-PGF1alpha was ineffective at the concentrations tested. On gastro-intestinal smooth muscle, PGI2 contracted strips of rat and hamster stomach and the chick rectum. It was less potent than PGE2 or PGF2alpha. None of these substances contracted the cat terminal ileum. 6-oxo-PGF1alpha was inactive on these tissues at the doses tested. PGI2 was less active than PGE2 or PGF2alpha in contracting guinea-pig trachea and rat uterus; 6-oxo-PGF1alpha was active only on the rat uterus. Thus, PGI2 can be distinguished from the other stable prostaglandins using the cascade method of superfusion. The cascade superfusion method was used to compare the effects of prostacyclin (PG12) and its stable metabolite 6-oxo-PGFla on various bioassay tissues with those of PGE2 and PGF2a. On vascular smooth muscle, PG12 was responsible for relaxation of all tissues tested except the rabbit aorta. PGE2 relaxed rabbit coeliac and mesenteric artery but contracted bovine coronary artery and had no effect on rabbit aorta. At the concentrations tested 6-oxo-PGFla was ineffective. On gastrointestinal smooth muscle, PG12 contracted strips of rat and hamster stomach and the chick rectum. It was less potent than PGE2 or PGE2a. None of these substances contracted the cat terminal ileum. 6-oxo-PGFla was inactive on these tissues at the dose tested. PG12 was less active than PGE2 or PGF2a in contracting guinea-pig trachea and rat uterus. 6-oxo-PGFla was active only on the rat uterus. In sum, with the cascade method of superfusion, PG12 can be distinguished from the other stable prostaglandins.
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