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  • Title: Serosurveillance of rabies antibodies in dogs in Mumbai region by using indirect ELISA.
    Author: Nale JM, Pharande RR, Majee SB, Gandge RS, Sawane MP, Ingle SA.
    Journal: Comp Immunol Microbiol Infect Dis; 2021 Jun; 76():101655. PubMed ID: 33930629.
    Abstract:
    Rabies is a highly fatal viral infection of the central nervous system affecting all warm-blooded animals including humans. To implement the preventive and control measures, it is important to decide the status of anti-rabies antibodies in dogs. Out of 120 serum samples, 47 (39.2 %) serum samples, showed an antibody titre equal to or above the cut off value of 0.5 IU/ml. The maximum number of dogs showed anti-rabies antibody titres equal to or above the cut-off value of 0.5 IU/ml after <1 month pre-exposure to the rabies vaccine. In 15 serum samples of pet dogs, we observed 13 (86.66 %) dogs with protective anti-rabies antibody titre. Statistical analysis suggests that the age of the animal had no significant effect on anti-rabies antibody titre in vaccinated pet dogs. The overall low seroprevalence of anti-rabies antibody in stray dogs indicates their susceptibility to rabies infection and thus posing a risk of rabies to other animals and humans.
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