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  • Title: A new flavonoid from the leaves of Garcinia mckeaniana Craib and α-glucosidase and acetylcholinesterase inhibitory activities.
    Author: Nguyen TTH, Nguyen VT, Van Cuong P, Nguyen Thanh T, Le Thi TA, Mai Huong DT, Truong BN, Litaudon M, Ninh The S.
    Journal: Nat Prod Res; 2022 Oct; 36(19):5074-5080. PubMed ID: 33939580.
    Abstract:
    From the ethyl acetate extract (EtOAc) of the Vietnamese Garcinia mckeaniana leaves, a new flavone 8-C-glycoside 2'',6''-di-O-acetylvitexin (1), together with six known analogs 2-7 were isolated. Their structures were determined by spectral methods and compared with literature data. In α-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC50 range of 9.17-97.53 µM, as compared with that of the positive control acarbose (249 µM). Flavones and biflavones showed are better than flavone glycosides in both α-glucosidase and acetylcholinesterase inhibitory activities[Formula: see text].
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