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Title: [Binding of K 1-3 and K 4 fragments of plasminogen containing lysine-binding sites with fibrinogen and its fragments]. Author: Tret'iachenko VG, Grinenko TV, Kudinov SA. Journal: Ukr Biokhim Zh (1978); 1988; 60(2):3-6. PubMed ID: 3394172. Abstract: Interaction of plasminogen K 1-3 and K 4 fragments containing lysine binding sites with fibrinogen and its fragments has been investigated. It has been established that K 1-3 fragment binds to fibrinogen and its E and DL fragments. K 4 fragment does not bind to E and DL fragments, but it interacts with fibrinogen. K 4 fragment does not interact with early fibrinogen proteolysis X2 fragment which differs from the native molecule of fibrinogen in the alpha C domain absence. The results obtained indicate that lysine binding sites located at plasminogen K 1-3 and K 4 fragments correspond to different fibrinogen molecule centres. The centre complementary to K 4 fragment lysine binding sites could be located at the fibrinogen alpha C domain.[Abstract] [Full Text] [Related] [New Search]