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  • Title: Identification of the 80-kDa protein that crosslinks to the cap structure of eukaryotic mRNAs as initiation factor eIF-4B.
    Author: Milburn SC, Pelletier J, Sonenberg N, Hershey JW.
    Journal: Arch Biochem Biophys; 1988 Jul; 264(1):348-50. PubMed ID: 3395129.
    Abstract:
    Preparations of either crude or purified protein synthesis initiation factors, when tested by crosslinking to the m7G-cap structure of mRNAs, exhibit specific crosslinking to an 80-kDa protein. Polyclonal antibodies specific for eIF-4B precipitate the 80-kDa cap-radiolabeled protein, thereby demonstrating that eIF-4B binds mRNA near its 5'-terminus.
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