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  • Title: Effect of GPIIb-IIIa complex ligands on calcium ion movement and cytoskeleton organization in activated platelets.
    Author: Sinigaglia F, Bisio A, Torti M, Balduini CL, Bertolino G, Balduini C.
    Journal: Biochem Biophys Res Commun; 1988 Jul 15; 154(1):258-64. PubMed ID: 3395329.
    Abstract:
    We studied the influence of the occupancy of the fibrinogen receptor (GP IIb-IIIa complex) on two early aspects of agonist induced platelet activation: the increase of the intracellular Ca2+ concentration and the cytoskeleton reorganization. A monoclonal antibody, a peptide containing the RGD sequence and fibrinogen purified from human plasma were used as GP IIb-IIIa ligands. The obtained results demonstrated that fibrinogen receptor occupancy inhibits Ca2+ movement and cytoskeleton reorganization caused by low thrombin concentration and ADP.
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