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  • Title: Pharmacokinetic disposition in sheep of various vitamin E preparations given orally or intravenously.
    Author: Hidiroglou M, Karpinski K.
    Journal: Br J Nutr; 1988 May; 59(3):509-18. PubMed ID: 3395610.
    Abstract:
    1. Increases in plasma tocopherol concentrations were compared in sheep after a single oral administration of (per kg body-weight): 67 mg D- and 91 mg DL-epimers of alpha-tocopherol, and 74 mg D- and 100 mg DL-epimers of alpha-tocopheryl acetate, or intravenous administration of DL-alpha-tocopherol and DL-epimers of DL-alpha-tocopheryl acetate. 2. The results showed that biological availability was higher after D-alpha-tocopherol dosing than after the other forms. Intravenous administration of D-alpha-tocopherol acetate was a more effective way of dosing in sheep than equivalent intravenous amounts of DL-alpha-tocopheryl acetate or DL-alpha-tocopherol.
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