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  • Title: Minimal change nephropathy and pemphigus vulgaris associated with penicillamine treatment of rheumatoid arthritis.
    Author: Savill JS, Chia Y, Pusey CD.
    Journal: Clin Nephrol; 1988 May; 29(5):267-70. PubMed ID: 3396226.
    Abstract:
    A 51-year-old man developed pemphigus vulgaris, minimal change nephropathy and acute tubular necrosis after 11 months of treatment with penicillamine for rheumatoid arthritis associated with features of Reiter's syndrome. Penicillamine is a polyclonal B lymphocyte activator in animals and precipitates a variety of autoimmune reactions in man. The pathogenesis of minimal change nephropathy is obscure, but our observations support the possibility that autoimmune mechanisms play a role.
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