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  • Title: Correlation between GPR, MHR and elderly essential hypertension with unstable angina pectoris.
    Author: Liu X, Zhang Y, Jin F, Liu H, Li Q, Gao Y, Hou R, Zhang Z.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2021 Apr 28; 46(4):373-378. PubMed ID: 33967083.
    Abstract:
    OBJECTIVES: To investigate the level and significance of serum γ-glutamyl transferase-to-platelet ratio (GPR) and monocyte count to high-density lipoprotein ratio (MHR) in patients with essential hypertension (EH) and unstable angina (UA). METHODS: A total of 218 patients with coronary angiography aged ≥60 years, who were admitted to the EH hospital of the Department of Cardiac Medicine, Affiliated Hospital of Chengde Medical College, were selected from September 2018 to September 2019. They were divided into an EH+UA group (n=113) and an EH group (n=105). In addition, 106 patients with normal coronary angiography who were diagnosed with coronary heart disease were selected as a control group. The general data, blood biochemical indicators, GPR and MHR in each group were compared, and partial correlation analysis and receiver operator characteristic (ROC) curve analysis were performed. RESULTS: Compared with the control group, patients in the EH+UA group and the EH group had higher body mass index (BMI), tyiglyceride (TG), GPR, and MHR, and lower high-density lipoprotein-cholesterol (HDL-C) (all P<0.05); and patients in the EH+UA group had higher white blood cell counts, alanine aminotransferase (ALT), and uric acid (all P<0.05). Compared with the EH group, patients in the EH+UA group had higher GPR and MHR (both P<0.05). Partial correlation analysis showed that after controlling the antihypertensive drugs and lipid-lowering drugs, GPR was found to be positively correlated with BMI, white blood cell count, ALT, TG, and uric acid (r=0.160, 0.111, 0.205, 0.250, 0.154, respectively, all P<0.05), which was negatively correlated with HDL-C (r=-0.238, P<0.05); MHR was positively correlated with BMI, ALT, TG, uric acid, and GPR (r=0.186, 0.307, 0.157, 0.141, 0.223, respectively, all P<0.05), and negatively correlated with HDL-C (r=-0.610, P<0.001). ROC curve analysis showed that GPR had higher specificity and positive predictive value, while MHR had higher sensitivity. When the two indicators were combined, the sensitivity and positive predictive value were higher. CONCLUSIONS: There is a correlation between GPR, MHR and EH combined with UA pectoris, and the combined detection of the two indicators has adjuvant diagnostic value for elderly EH combined with UA. 目的: 探讨老年原发性高血压(essential hypertension,EH)合并不稳定型心绞痛(unstable angina,UA)患者血清γ-谷氨酰基转移酶与血小板比值(γ-glutamyl transferase-to-platelet ratio,GPR)、单核细胞与高密度脂蛋白胆固醇比值(monocyte count to high-density lipoprotein ratio,MHR)的水平及意义。方法: 选取2018年9月至2019年9月承德医学院附属医院心脏内科以EH收入院且年龄≥60岁并行冠状动脉造影的患者218例,根据是否合并UA分为EH+UA组(n=113)和EH组(n=105),另选择疑诊冠心病入院冠状动脉造影正常的患者为对照组(n=106)。比较各组患者的一般资料、血生化指标、GPR及MHR的差异,并进行偏相关分析及受试者工作特征(receiver operator characteristic,ROC)曲线分析。结果: 与对照组相比,EH+UA组、EH组患者体重指数(body mass index,BMI)、三酰甘油(tyiglyceride,TG)、GPR、MHR均升高,高密度脂蛋白胆固醇(high-density lipoprotein-cholesterol,HDL-C)降低(均 P<0.05);EH+UA组患者白细胞计数、丙氨酸转氨酶(alanine aminotransferase,ALT)、尿酸水平均升高(均P<0.05);与EH组相比,EH+UA组患者GPR、MHR均升高(均P<0.05)。偏相关分析显示:在控制降压药及降脂药后,GPR与BMI、白细胞计数、ALT、TG、尿酸均呈正相关(分别r=0.160、0.111、0.205、0.250、0.154,均P<0.05),与HDL-C呈负相关(r=-0.238,P<0.05);MHR与BMI、ALT、TG、尿酸、GPR均呈正相关(分别r=0.186、0.307、0.157、0.141、0.223,均P<0.05),与HDL-C呈负相关(r=-0.610,P<0.001)。ROC曲线分析表明GPR具有较高特异性和阳性预测价值,而MHR具有较高的敏感度,当两指标联合检测时,敏感度及阳性预测价值更高。结论: GPR、MHR与EH+UA存在相关性,且两指标联合检测对老年EH+UA具有一定的辅助诊断价值。. OBJECTIVE: To investigate the level and significance of serum γ-glutamyl transferase-to-platelet ratio (GPR) and monocyte count to high-density lipoprotein ratio (MHR) in patients with essential hypertension (EH) and unstable angina (UA). METHODS: A total of 218 patients with coronary angiography aged ≥60 years, who were admitted to the EH hospital of the Department of Cardiac Medicine, Affiliated Hospital of Chengde Medical College, were selected from September 2018 to September 2019. They were divided into an EH+UA group (n=113) and an EH group (n=105). In addition, 106 patients with normal coronary angiography who were diagnosed with coronary heart disease were selected as a control group. The general data, blood biochemical indicators, GPR and MHR in each group were compared, and partial correlation analysis and receiver operator characteristic (ROC) curve analysis were performed. RESULTS: Compared with the control group, patients in the EH+UA group and the EH group had higher body mass index (BMI), tyiglyceride (TG), GPR, and MHR, and lower high-density lipoprotein-cholesterol (HDL-C) (all P<0.05); and patients in the EH+UA group had higher white blood cell counts, alanine aminotransferase (ALT), and uric acid (all P<0.05). Compared with the EH group, patients in the EH+UA group had higher GPR and MHR (both P<0.05). Partial correlation analysis showed that after controlling the antihypertensive drugs and lipid-lowering drugs, GPR was found to be positively correlated with BMI, white blood cell count, ALT, TG, and uric acid (r=0.160, 0.111, 0.205, 0.250, 0.154, respectively, all P<0.05), which was negatively correlated with HDL-C (r=-0.238, P<0.05); MHR was positively correlated with BMI, ALT, TG, uric acid, and GPR (r=0.186, 0.307, 0.157, 0.141, 0.223, respectively, all P<0.05), and negatively correlated with HDL-C (r=-0.610, P<0.001). ROC curve analysis showed that GPR had higher specificity and positive predictive value, while MHR had higher sensitivity. When the two indicators were combined, the sensitivity and positive predictive value were higher. CONCLUSION: There is a correlation between GPR, MHR and EH combined with UA pectoris, and the combined detection of the two indicators has adjuvant diagnostic value for elderly EH combined with UA.
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