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  • Title: Effect of recombinant human erythropoietin on the anemia of chronic renal failure.
    Author: Urabe A, Takaku F, Mizoguchi H, Kubo K, Ota K, Shimizu N, Tanaka K, Mimura N, Nihei H, Koshikawa S.
    Journal: Int J Cell Cloning; 1988 May; 6(3):179-91. PubMed ID: 3397592.
    Abstract:
    Phase I and Phase II studies of recombinant human erythropoietin (rhEpo) were conducted in normal volunteers and in anemic patients with chronic renal failure on maintenance hemodialysis. Three hundred U/person of rhEpo was administered intravenously to healthy normal volunteers in the Phase I study, resulting in no subjective or objective changes. In the Phase II study, 66 patients with chronic renal failure on maintenance hemodialysis with less than 20% hematocrit values were treated with rhEpo in doses of 50 U/kg to 200 U/kg two or three times a week. Hematocrit values increased significantly during the 12 weeks, and the patients' conditions improved. Patients previously requiring blood transfusions became transfusion-independent during our study. There were no obvious side effects, thus indicating the safety and efficacy of rhEpo in the anemia of chronic renal failure.
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