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  • Title: Integrating multiparametric MRI radiomics features and the Vesical Imaging-Reporting and Data System (VI-RADS) for bladder cancer grading.
    Author: Zheng Z, Xu F, Gu Z, Yan Y, Xu T, Liu S, Yao X.
    Journal: Abdom Radiol (NY); 2021 Sep; 46(9):4311-4323. PubMed ID: 33978825.
    Abstract:
    PURPOSE: Pathological grade is important for the treatment selection and outcome prediction in bladder cancer (BCa). We aimed to construct a radiomics-clinical nomogram to preoperatively differentiate high-grade BCa from low-grade BCa. METHODS: A total of 185 BCa patients who received multiparametric MRI (mpMRI) before surgery between August 2014 and April 2020 were enrolled in our study. Radiomics features were extracted from the largest tumor located on dynamic contrast-enhancement and T2WI images. After feature selection, the synthetic minority over-sampling technique (SMOTE) was performed to balance the minority group (low-grade group). Radiomics signatures were constructed in the training set and assessed in the validation set. Univariable and multivariable logistic regression were applied to build a nomogram. RESULTS: The radiomics signature generated by the least absolute shrinkage and selection operator model achieved the optimal performance for BCa grading in both the SMOTE-balanced training [accuracy: 93.2%, area under the curve (AUC): 0.961] and validation sets (accuracy: 89.9%, AUC: 0.952). A radiomics-clinical nomogram incorporating the radiomics signature and the Vesical Imaging-Reporting and Data System (VI-RADS) score had novel calibration and discrimination both in the training (AUC: 0.956) and validation sets (AUC: 0.958). Decision curve analysis presented the clinical utility of the nomogram for decision-making. CONCLUSIONS: The mpMRI-based radiomics signature had the potential to preoperatively predict the pathological grade of BCa. The proposed nomogram combining the radiomics signature with the VI-RADS score improved the diagnostic power, which may aid in clinical decision-making.
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