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  • Title: Platelet autoantibody specificity and response to rhTPO treatment in patients with primary immune thrombocytopenia.
    Author: Yu Y, Hou Y, Zhao Y, Zhou H, Jing F, Liu Y, Peng J, Liu X, Hou M.
    Journal: Br J Haematol; 2021 Jul; 194(1):191-194. PubMed ID: 33993469.
    Abstract:
    This retrospective study aimed to evaluate the relationship between plasma autoantibody species and rhTPO response in adult ITP patients who failed the first-line treatments. Plasma anti-glycoprotein (GP) IIb/IIIa and anti-GPIb/IX autoantibodies were detected in 47·2% and 40·6% of the 123 patients, respectively. Overall response rate to rhTPO treatment in patients without anti-GPIb/IX autoantibodies was significantly higher than patients with anti-GPIb/IX autoantibodies (82·2% vs. 60·0%, P = 0·006). By contrast, no statistical difference in response rate was observed between patients with or without anti-GPIIb/IIIa autoantibodies (74·1% vs. 72·3%, P = 0·819). Therefore, the presence of anti-GPIb/IX autoantibodies might serve as a predictive factor for poor response to rhTPO treatment in ITP.
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