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  • Title: Immunohistochemical localization of the terminal C5b-9 complement complexes associated to S-protein and macrophage immunoreactive deposits in human damaged myocardial areas.
    Author: Vlaicu R, Rus HG, Niculescu F.
    Journal: Med Interne; 1988; 26(1):21-7. PubMed ID: 3399815.
    Abstract:
    The indirect and double-labelling immunoperoxidase techniques were used to localize the C5b-9 neoantigens, S-protein and macrophage immunoreactive deposits in myocardial areas with necrosis and sclerosis. Granular masses of C5b-9 neoantigens, diffuse areas of S-protein and nucleated and anucleated immunoreactive deposits of macrophage origin were localized in damaged myocardial areas but not in areas free of lesion. The presence of C5b-9 neoantigens associated to S-protein and macrophage deposits is suggestive for a local complement activation in the complex heterolytic events of myocardial injury.
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