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Title: [Comparison of efficacy between laparoscopic and open proximal gastrectomy with double-tract reconstruction for Siewert type Ⅱ and Ⅲ adenocarcinoma of the esophagogastric junction].
Author: Ma F, Peng LQ, Liu CP, Zhang YL, Wang L, Zhang B, Ma Q, Ji SQ, Chai JH, Tang XC, Zhao EJ, Hua YW.
Journal: Zhonghua Wei Chang Wai Ke Za Zhi; 2021 May 25; 24(5):420-425. PubMed ID: 34000771.
Abstract:
Objective: To compare the efficacy between laparoscopic and open proximal gastrectomy with double-tract reconstruction for Siewert type II and III adenocarcinoma of the esophagogastric junction (AEG). Methods: A retrospective cohort study was conducted. Inclusion criteria: (1) 18 to 80 years old; (2) Siewert II and III AEG was confirmed by preoperative gastroscopy and biopsy, which could not be resected by endoscopy; patients undergoing radical proximal gastrectomy with double-tract reconstruction; (3) contrast-enhanced abdominal CT staging was cT1-2N0M0; (4) Eastern Cooperative Oncology Group (ECOG) physical status score <2 points, American Association of Anesthesiologists (ASA) grade 1 to 2; (5) patients agreed to perform proximal gastrectomy and signed an informed consent. Those who had undergone neoadjuvant radiochemotherapy, suffered from serious mental diseases and had incomplete data were excluded. According to the above criteria, clinical data of 84 consecutive patients with Siewert II and III AEG undergoing surgery at General Surgery Department of The Affiliated Tumor Hospital of Zhengzhou University from October 2010 to December 2018 were collected and analyzed. Of 84 patients, 61 underwent open proximal gastrectomy with double-tract reconstruction (OPG group), while 23 underwent laparoscopic proximal gastrectomy with double-tract reconstruction (LPG group). The perioperative complications and postoperative reflux esophagitis of two groups were compared. A P-value of <0.05 was considered to be statistically significant. Results: Among 84 cases, 74 were male and 10 were female. There were 43 cases of Siewert type II and 41 cases of Siewert type III. There were no significant differences in age, gender, body mass index, comorbidities, Siewert type, and tumor staging between the two groups (all P>0.05). As compared to the OPG group, the LPG group had longer operation duration [(223±21) minutes vs. (161±14) minutes, t=15.352, P<0.001], less intraoperative blood loss [195 (150, 215) ml vs. 208 (192, 230) ml, Z=2.143, P=0.032], and shorter time to flatus [(2.8±0.7) days vs. (3.3±0.9) days, t=2.477, P=0.015]. There were no significant differences in the number of harvested lymph nodes, time to the first meal and postoperative hospital stay between the two groups (all P>0.05). Postoperative complications developed in 2 cases (8.7%, 1 case each for anastomotic leakage and intestinal obstruction) in the LPG group and 5 cases (8.2%, 1 case each for anastomotic leakage, anastomotic bleeding, and anastomotic stenosis, 2 cases of incision infection) in the OPG group (χ(2)=5.603, P=0.231). The median follow-up was 41.2 (12.8-110.5) months. One patient (1.6%,1/61) had obvious reflux symptoms in the OPG group, compared with none in the LPG group (χ(2)=0.644, P=0.422). Esophagitis occurred in 1 case (4.8%, 1/21) in LPG group, compared with 4 patients (7.1%, 4/56) in the OPG group, without significant difference between the two groups (χ(2)=0.505, P=0.477). Conclusion: Laparoscopic proximal gastrectomy with double-tract reconstruction is safe and feasible without increasing the risk of postoperative complication and reflux esophagitis. 目的： 分析比较完全腹腔镜与开放近端胃切除双通道吻合法治疗Siewert Ⅱ、Ⅲ型食管胃结合部腺癌的疗效。 方法： 采用回顾性队列研究方法。病例纳入标准：（1）18~80岁；（2）术前经胃镜和活检证实为Siewert Ⅱ、Ⅲ型食管胃结合部腺癌，不可内镜下切除并接受根治性近端胃切除双通道吻合术；（3）腹部增强CT诊断为cT(1~2)N(0)M(0)；（4）美国东部肿瘤协作组（ECOG）体力状态评分<2分，美国麻醉医师协会（ASA）分级为1~2级；（5）同意行近端胃切除术并签署知情同意书。排除已行新辅助放化疗、患有严重精神疾病和资料不全者。根据上述标准，分析2010年10月至2018年12月期间，在郑州大学附属肿瘤医院普通外科治疗的连续84例Siewert Ⅱ、Ⅲ型食管胃结合部腺癌患者的临床资料，其中61例接受开放近端胃切除双通道吻合术（开放手术组），23例接受完全腹腔镜近端胃切除双通道吻合术（完全腹腔镜手术组）。比较两组患者的围手术期并发症发生情况和术后反流性食管炎发生情况。 结果： 84例患者中，男74例，女10例。Siewert Ⅱ型43例，Siewert Ⅲ型41例。开放手术组和完全腹腔镜手术组在年龄、性别、体质指数、合并症、肿瘤分化程度、Siewert分型和肿瘤分期等方面的差异无统计学意义（均P>0.05）。完全腹腔镜手术组手术时间较开放手术组长[（223±21）min比（161±14）min，t=15.352，P<0.001]，但术中中位出血量[195（150，215）ml比208（192，230）ml，Z=2.143，P=0.032]较少，术后排气时间[（2.8±0.7）d比（3.3±0.9）d，t=2.477，P=0.015]较早，差异均有统计学意义。两组淋巴结检出数、术后首次进食时间和术后住院时间差异均无统计学意义（均P>0.05）。完全腹腔镜手术组和开放手术组分别有2例（8.7%，吻合口漏和肠梗阻各1例）和5例（8.2%，分别为吻合口漏、吻合口出血、吻合口狭窄各1例，切口感染2例）出现术后并发症，差异无统计学意义（χ(2)=5.603，P=0.231）。术后中位随访41.2（12.8~110.5）个月，开放手术组中有1例（1.6%，1/61）出现明显反流症状，完全腹腔镜手术组无一例出现反流症状，差异无统计学意义（χ(2)=0.644，P=0.422）；完全腹腔镜手术组和开放手术组分别有1例（4.8%，1/21）和4例（7.1%，4/56）出现反流性食管炎表现，差异无统计学意义（χ(2)=0.505，P=0.477）。 结论： 腹腔镜近端胃切除双通道吻合术手术安全可行，不会增加术后并发症及反流性食管炎的发生风险。.

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