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Title: [Clinical observation of herb-separated moxibustion on segmental conception vessel combined with low-frequency TEAS for asthenospermia and oligospermia].
Author: Fang LQ, Li XL, Yuan SS, Zhang QW, Han DX.
Journal: Zhongguo Zhen Jiu; 2021 May 12; 41(5):515-20. PubMed ID: 34002565.
Abstract:
OBJECTIVE: To observe the clinical effect of herb-separated moxibustion on segmental conception vessel combined with low-frequency transcutaneous electrical acupoint stimulation (TEAS) for asthenospermia and oligospermia. METHODS: A total of 105 patients with asthenospermia and oligospermia were randomly divided into a combination group, a TEAS group and a medication group, 35 cases in each one. In the medication group, vitamin E capsules, coenzyme Q10 capsules，Wuzi Yanzong pills were taken. In the TEAS group, TEAS was applied at Shenshu (BL 23) and Pishu (BL 20), 2 Hz in frequency, 10-15 mA in intensity, once every 2 days, 30 min each time.On the base of the treatment as the TEAS group, herb-separated moxibustion on segmental conception vessel [Shenque (CV 8) to Zhongji (CV 3)] was applied in the combination group, once every 10 days. A total of 3 months were required in the 3 groups.Before treatment and 2, 3 months into treatment, the semen routine indexes (concentration, normal morphology rate, sperm motility), seminal plasma contents of superoxide dismutase (SOD) and malondialdehyde (MDA) and TCM syndrome score were observed in the 3 groups, and the clinical efficacy was evaluated. RESULTS: Compared before treatment, except for the sperm morphology 2 months into treatment in the medication group, the semen routine indexes 2, 3 months into treatment were improved in the 3 groups (P<0.01), and the semen routine indexes 2, 3 months into treatment in the combination group were superior to the medication group and the TEAS group (P<0.01). Compared before treatment, the seminal plasma contents of SOD were increased and MDA were decreased 2, 3 months into treatment in the 3 groups (P<0.01), and the changes of the combination group were larger than the medication group and the TEAS group (P<0.01). Compared before treatment, the TCM syndrome scores 2, 3 months into treatment in the combination group, and 3 months into treatment in the medication group and the TEAS group were decreased (P<0.01). The TCM syndrome scores 2, 3 months into treatment in the combination group were lower than the medication group and the TEAS group (P<0.01). The total effective rates in the combination group, the medication group and the TEAS group were 85.7% (30/35), 68.6% (24/35) and 65.7% (23/35), the clinical efficacy of the combination group was higher than the medication group and the TEAS group (P<0.05). CONCLUSION: Herb-separated moxibustion on segmental conception vessel combined with low-frequency TEAS can improve semen routine, reduce sperm oxidative stress damage for patients with asthenospermia and oligospermia, and the clinical efficacy is better than the medication and TEAS. 目的：观察任脉区段药物铺灸联合低频经皮穴位电刺激（TEAS）治疗少弱精子症的临床疗效。方法：将105例少弱精子症患者随机分为联合组、低频组和药物组，每组35例。药物组采用口服维生素E软胶囊、辅酶Q10胶囊、五子衍宗丸治疗；低频组取肾俞、脾俞进行TEAS治疗（2 Hz，10~15 mA），隔日1次，每次30 min；联合组在低频组的基础上，予以任脉区段（神阙至中极）药物铺灸治疗，每10天治疗1次。均治疗3个月。观察各组患者治疗前及治疗2、3个月后的精液常规（浓度、正常形态率、精子活力）、精浆超氧化物歧化酶（SOD）和丙二醛（MDA）含量及中医证候积分，并评定临床疗效。结果：①与治疗前比较，除药物组治疗2个月后精子形态指标外，3组患者治疗2、3个月后精液常规各项指标均改善（P<0.01）；联合组治疗2、3个月后精液常规各项指标均优于药物组和低频组（P<0.01）。②与治疗前比较，3组患者治疗2、3个月后精浆SOD含量升高、MDA含量降低（P<0.01），且变化幅度联合组均大于其他两组（P<0.01）。③与治疗前比较，联合组治疗2、3个月后及药物组、低频组治疗3个月后中医证候积分降低（P<0.01）；治疗2、3个月后，联合组中医证候积分低于药物组和低频组（P<0.01）。④联合组、药物组、低频组总有效率分别为85.7%（30/35）、68.6%（24/35）、65.7%（23/35），联合组临床疗效优于药物组和低频组（P<0.05）。结论：任脉区段药物铺灸联合低频TEAS治疗可改善少弱精子症患者的精液常规，降低精子氧化应激损伤，临床疗效优于药物和TEAS治疗。.

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