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  • Title: Atropine infusions near the sexually dimorphic area of the gerbil hypothalamus facilitate hormonal induction of scent marking.
    Author: Yahr P, Kief ML, Commins D.
    Journal: Behav Brain Res; 1988 Jul; 29(1-2):185-90. PubMed ID: 3401318.
    Abstract:
    The sexually dimorphic area (SDA) of the gerbil hypothalamus contains cells in which acetylcholinesterase activity is stimulated by testosterone. These cells are probably cholinoceptive. Because cholinoceptive cells and the SDA are both implicated in hormonal control of gerbil scent marking, marking was studied in castrated males given a low dose of testosterone systemically, and atropine, a cholinergic antagonist, near the SDA. Controls received saline near the SDA or atropine in the thalamus. Subjects were also tested for male sexual behavior, since it is also affected by the SDA. Infusing 25-35 micrograms atropine methyl nitrate near the SDA twice a week facilitated marking but did not affect mating. Experimental males marked more, whereas controls marked less, while receiving infusions, than they did before castration. The two control groups did not differ from each other. After infusions stopped, marking by experimental males decreased, though residual effects were detected in one test setting. The data suggest that a cholinoceptive system in or near the SDA participates in hormonal control of gerbil scent marking.
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