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  • Title: [Effect of the calcium antagonist nifedipine on central and peripheral hemodynamics in patients with primary pulmonary hypertension].
    Author: Khosseĭn A, Mareev VIu, Ageev FT, Sazonova LN, Lobova NM.
    Journal: Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR; 1988; 11(1):78-81. PubMed ID: 3401345.
    Abstract:
    15 patients with primary pulmonary hypertension (PPH) were studied. An acute test with 20 mg nifedipine (N) sublingually was performed and the pulmonary artery pressure (PAP) was measured. N had manifest arterolodilating effect in the systemic and especially pulmonary circulation, induced decrease in the total peripheral and total pulmonary vascular resistance (TPerVR and TPulVR) by 21.7 and 25.3%, correspondingly. N had principal effect on pulmonary arterioles (TPerVR/TPulVR ratio increased by 16.9%). Systolic and diastolic PAP decreased in this case by 15.2 and 18.4%, correspondingly. All the patients demonstrated increase in cardiac output (on the average by 17.0%) and insignificant increase in heart rate (7.4%).
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