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  • Title: The levator ani of the female rat: a suitable model for studying the effects of testosterone on the development of mammalian muscles.
    Author: Tobin C, Joubert Y.
    Journal: Biol Struct Morphog; 1988; 1(1):28-33. PubMed ID: 3401520.
    Abstract:
    The present results give evidence by using cytochemical markers of motor end-plates (ChE, AchR) and ultrastructural techniques that the Levator ani (LA) muscle is also present in adult females: it is composed of differentiated and innervated fibres. A significant difference, both on the number of fibres per muscle (n) and on their average cross-sectional area (acsa), was observed between sexes:-male: n = 5300 +/- 687, acsa: 522 +/- 68.6 microns 2;-female: n = 565 +/- 246.9, acsa: 68 +/- 8.6 microns 2. These results suggest that testosterone could control, at least partially, the number and the diameter of muscle fibres during development.
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