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  • Title: [Effect of a stable analog of leu-enkephalin, dalargin, on the cell division of the corneal epithelium in white rats].
    Author: Pan'kova TD, Timoshin SS, Radivoz MI, Titov MI.
    Journal: Biull Eksp Biol Med; 1988 Jul; 106(7):97-9. PubMed ID: 3401587.
    Abstract:
    The effect of Leu-enkephalin analog--dalargin--on the corneal epithelium proliferation has been studied in white rats. 10 microliter dalargin per 1 kg body weight were administered intraperitoneally at 8 a.m. The mitotic index (MI), DNA synthesis cell index and label intensity (LI) were determined every 4 hours over a 24-hour period. The results obtained demonstrate that dalargin stimulates DNA synthesis in cells throughout the entire period of action. MI increased only 4, 8, 12 hours after dalargin administration. Mean daily DNA synthesis cell index and MI increased 2.1-fold and 3.1-fold, respectively after dalargin administration. It is suggested that dalargin activates the cell division processes by speeding up mitosis, shortening the premitotic period, accelerating the speed of the DNA synthesis and increasing cell proliferation pool.
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