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  • Title: Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas.
    Author: Heitzer AM, Kahalley LS, Minard CG, Stafford C, Grosshans DR, Okcu MF, Raghubar KP, Gragert M, McCurdy M, Warren EH, Gomez J, Ris MD, Paulino AC, Chintagumpala M.
    Journal: Pediatr Blood Cancer; 2021 Aug; 68(8):e29096. PubMed ID: 34019329.
    Abstract:
    The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low- and intermediate-grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/verbal reasoning, working memory, and processing speed postradiotherapy. The median age at diagnosis was 8.2 years (range 1.0-14.7) and the median age at PRT was 9.9 years (range 4.2-17.0). Patients' neurocognitive performance did not change on any measure following PRT (p ≥ .142). We did not observe significant changes in cognitive function over time among a small group of LIGG patients treated with PRT.
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