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  • Title: Reduction of aspirin-induced gastrointestinal bleeding with cimetidine.
    Author: Welch RW, Bentch HL, Harris SC.
    Journal: Gastroenterology; 1978 Feb; 74(2 Pt 2):459-63. PubMed ID: 340334.
    Abstract:
    Aspirin induces gastric mucosal damage and bleeding in the presence of acid. Cimetidine, the histamine H2-receptor antagonist, reduces basal and stimulated acid secretion. Arthritic patients taking fixed doses of aspirin who were found to have aspirin-induced occult gastrointestinal bleeding were given cimetidine in a randomized double blind, crossover study. Autologous 51Cr-labeled blood was measured in 4-day stool collections at the end of each 4-week period of placebo and cimetidine therapy in 22 acid-producing patients. Mean daily fecal blood loss was reduced during cimetidine therapy to 2.2 +/- 0.3 ml per day, compared with 4.1 +/- 0.7 ml per day during placebo therapy (P= 0.002).
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