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  • Title: Treatment of cyclophosphamide-induced hemorrhagic cystitis in five dogs.
    Author: Laing EJ, Miller CW, Cochrane SM.
    Journal: J Am Vet Med Assoc; 1988 Jul 15; 193(2):233-6. PubMed ID: 3403354.
    Abstract:
    Sterile hemorrhagic cystitis developed in 5 dogs after treatment with cyclophosphamide. Four dogs were being treated with various antineoplastic protocols, and the fifth dog had recurrent immune-mediated thrombocytopenia. In all instances, clinical signs of hematuria and stranguria persisted after cyclophosphamide administration was discontinued. Three dogs required cystotomy to remove necrotic mucosa and calculi. The other 2 dogs were treated with intravesicularly administered dimethyl sulfoxide to decrease inflammation and to inhibit fibroplasia of the bladder wall. In 4 dogs, clinical signs resolved after treatment. The fifth dog, treated surgically, continued to have intermittent urinary incontinence attributable to residual bladder wall fibrosis.
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