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  • Title: Determination of N-desmethyldiazepam in plasma by gas chromatography with an internal standard.
    Author: Viala A, Cano JP, Reynier JP, Rispe R.
    Journal: J Chromatogr; 1978 Jan 11; 147():349-57. PubMed ID: 340466.
    Abstract:
    N-Desmethyldiazepam in plasma has been determined by gas chromatography with electron capture detection, using N-desmethyltetrazepam as internal standard and a column filled Poly-A 103 on Gas-Chrom Q. No prior transformation of benzodiazepines is necessary. The sensitivity is ca.1 ng/ml and the recovery is greater than or equal to 70%. The method is particularly suitable for the pharmacokinetic study of dipotassium clorazepate: the amount of unchanged clorazepate may be estimated from the difference between the amount of N-desmethyldiazepam present initially and the total amount of N-desmethyldiazepam obtained after acidic treatment of the sample; the method is also useful for therapeutic control and for analytical toxicology.
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