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  • Title: Clinical analysis of patients with primary and secondary extranodal natural killer/T-cell lymphoma of central nervous system.
    Author: Li X, Yu H, Fu X, Zhang L, Li X, Li L, Wang X, Sun Z, Zhang X, Li Z, Wu J, Chang Y, Yan J, Zhou Z, Nan F, Wu X, Tian L, Zhang M.
    Journal: Hematol Oncol; 2023 Apr; 41(2):267-274. PubMed ID: 34061378.
    Abstract:
    Extranodal natural killer (NK)/T-cell lymphoma (NKTL) is a rare non-Hodgkin lymphoma that rarely arise exclusively in or metastasizes to the central nervous system (CNS). Globally, CNS involvement of NKTL heralds a serious prognosis and there is no standard treatment. 19 of 414 patients (4.59%) with ENKL followed were diagnosed with CNS involvement between 2006 and 2020. Two patients had primary CNS (PCNS) NKTL, and 17 patients had secondary CNS (SCNS) invasion. A total of 9 patients survived and 10 patients died. The median overall survival time was 55 months, and the median survival time after CNS invasion was 17 months. The 5-year cumulative survival probability was 45.7%. In conclusion, CNS risk evaluation and prophylaxis treatment can be carried out for patients with NK/T-cell lymphoma prognostic index risk group III/IV. In terms of treatment, systemic therapy based on methotrexate combined with radiotherapy and intrathecal chemotherapy can be selected.
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