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  • Title: Cholinergic REM sleep induction by arecoline in normal subjects: relation to thyroid function.
    Author: Keshavan M, Dubé S, Grabowski J, Sitaram N.
    Journal: Psychiatry Res; 1988 Jun; 24(3):333-6. PubMed ID: 3406243.
    Abstract:
    Serum thyroid hormones and the speed of rapid eye movement (REM) sleep induction by the central muscarinic agonist arecoline were measured in 21 normal volunteers. The arecoline-REM induction latencies had a modestly significant negative correlation with free thyroxine index. This finding is discussed in the light of observations in animal studies that thyroid hormones stimulate central cholinergic neuronal function.
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