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  • Title: Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1.
    Author: He Q, Ye A, Ye W, Liao X, Qin G, Xu Y, Yin Y, Luo H, Yi M, Xian L, Zhang S, Qin X, Zhu W, Li Y.
    Journal: Cell Death Dis; 2021 Jun 04; 12(6):576. PubMed ID: 34088891.
    Abstract:
    Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells. MiR-21-5p suppressed Krev interaction trapped protein 1 (KRIT1) in recipient HUVECs and subsequently activated β-catenin signaling pathway and increased their downstream targets VEGFa and Ccnd1, which consequently promoted angiogenesis and vascular permeability in CRC. A strong inverse correlation between miR-21-5p and KRIT1 expression levels was observed in CRC-adjacent vessels. Furthermore, miR-21-5p expression in circulating exosomes was markedly higher in CRC patients than in healthy donors. Thus, our data suggest that exosomal miR-21-5p is involved in angiogenesis and vascular permeability in CRC and may be used as a potential new therapeutic target.
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