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Title: [Use of trental for correcting the pharmacological effects caused by voltaren and indomethacin]. Author: Stepaniuk GI, Lutsiuk NB, Piskun RP, Smirnova OV, Cherviak MN. Journal: Farmakol Toksikol; 1988; 51(3):56-7. PubMed ID: 3410028. Abstract: Treatment of the adjuvant disease in rats by intragastric administration of voltaren or indomethacin (3 mg/kg) was followed by approximately equal anti-inflammatory and analgesic effects on the affected joints. In this case the development of active dystrophic changes in the gastrointestinal tract and kidneys was observed. At combined administration of the antiphlogistics with trental there was noted an enhancement of their therapeutic action on the joints and also a weakening of the ulcerogenic effect and nephrotoxicity that was reflected in the clinical, pathological, morphological and laboratory studies.[Abstract] [Full Text] [Related] [New Search]