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  • Title: [Immunomodulating properties of khlotazol].
    Author: Evnin DN, Khadzhaĭ IaI, Novikov VV, Klykova GT, Kedrovskaia MV.
    Journal: Farmakol Toksikol; 1988; 51(3):80-2. PubMed ID: 3410037.
    Abstract:
    A nonsteroidal anti-inflammatory agent khlotazol administered to rats in doses of 40-80 mg/kg for 5 days stimulated synthesis of IgM- and IgG-antibodies to ram erythrocytes and increased the number of antibody-forming cells (AFC) and rosette-forming cells (RFC) in the spleen. When the doses were increased to 160-320 mg/kg, the stimulating effect of the drug on the production of hemagglutinins retained but dose-dependent inhibition of the number of AFC and RFC was found. When administered in a dose of 80 mg/kg khlotazol markedly activated the reaction of hypersensitivity of delayed type induced by ram erythrocytes.
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