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  • Title: Validity testing of the TDx Cocaine Metabolite Assay with human specimens obtained after intravenous cocaine administration.
    Author: Cone EJ, Menchen SL, Mitchell J.
    Journal: Forensic Sci Int; 1988 Jun; 37(4):265-75. PubMed ID: 3410396.
    Abstract:
    Clinical specimens obtained from human subjects after intravenous cocaine administration were analyzed by the TDx Cocaine Metabolite Assay (TDx) and by GC/MS for benzoylecgonine. The TDx results were significantly correlated with results by GC/MS assay with no evidence of bias in the TDx assay. All cocaine metabolite positive specimens (greater than or equal to 300 ng/ml) were confirmed by GC/MS. Detection times to the last positive specimen by TDx assay and GC/MS assay of four subjects after a 20-mg intravenous dose of cocaine ranged from 29.3 to 39.1 h and 27.9 and 36.6 h, respectively. Overall, the TDx assay was found to be highly specific and accurate for the detection and measurement of benzoylecgonine in urine.
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