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Title: [Genetic Polymorphism of Antigens in Twelve Rare Blood Group Systems of Li Nationality in Hainan Province].
Author: Fu XL, Cai XQ, Yang SP, Wu B, Wu LN, Zhao XD, Weng AH, Xia L.
Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2021 Jun; 29(3):917-923. PubMed ID: 34105494.
Abstract:
OBJECTIVE: To explore the distribution characteristics of main antigen gene frequencies of Duffy,Diego,Kidd,Dombrock,MNS,Lutheran,Kell,Colton,Scianna,Yt,Knops and Indian in red blood cell blood group system of Li nationality in Hainan Province. METHODS: Antigens in twelve rare blood group systems of 214 Li people in Hainan Province were genotyped and analyzed by polymerase chain reaction-sequence specific primers (PCR-SSP). RESULTS: The gene frequency of antigens in twelve rare blood group systems of 214 Li people in Hainan Province including: the gene frequency of Duffy blood group system: fy^a=0.9556，fy^b=0.0444；the gene frequency of Diego blood group system: Di^a=0.0678，Di^b=0.9322；the gene frequency of Kidd blood group system：JK^a=0.4533，JK^b=0.5467；the gene frequency of Dombrock blood group system：DO^a=0.1051，DO^b=0.8949；the gene frequency of MNS blood group system：M=0.8131，N=0.1869,S=0.0327，s=0.9673，Mur⁺=0.5748，Mur^-=0.4252；the gene frequency of Lutheran blood group system：AU^a=0.8318，AU^b=0.1682；the Kell, Colton, Scianna, Yt, Knops and Indian blood type systems showed a monomorph and the genotype was kk, co^aco^a, Sc1Sc1, Yt^aYt^a, Kn^aKn^a and In^bIn^b. The observed and expected genotype values in twelve rare blood group systems of Li nationality in Hainan province were obeyed by the Hardy-Weinberg genitic rules. The difference between the observed and expectated values of the Kidd blood group system showed significant differences（χ²=17.1946，P=0.0002）. CONCLUSION: The genetic distribution and genetic status in twelve rare blood group systems of Li nationality in Hainan Province are relatively stable. The gene distribution of Duffy, Diego, Kidd, Drombrock, MNS and Lutheran blood group systems are polymorphic and show unique distribution characteristics compared with other regions and different nationalities. The gene frequency distribution of Kell、Colton、Scianna、Yt、Knops、Indian blood group systems are monomorphic. 题目: 海南省黎族人群12个红细胞稀有血型系统抗原基因的多态性研究. 目的: 探索海南省黎族人群Duffy、Diego、Kidd、Dombrock、MNS、Lutheran、Kell、Colton、Scianna、Yt、Knops和Indian等12个红细胞血型系统主要抗原基因频率的分布特征. 方法: 采用聚合酶链式反应-序列特异性引物法(PCR-SSP)对214名海南省黎族人群12个红细胞稀有血型系统抗原基因进行分型和多态性分析. 结果: 海南省黎族人群12个红细胞血型系统抗原基因频率为：Duffy血型系统基因频率：fy^a=0.9556，fy^b=0.0444；Diego血型系统基因频率：Di^a=0.0678，Di^b=0.9322；Kidd血型系统基因频率：JK^a=0.4533，JK^b=0.5467；Dombrock血型系统基因频率：DO^a=0.1051，DO^b=0.8949；MNS血型系统基因频率：M=0.8131，N=0.1869,S=0.0327，s=0.9673，Mur⁺=0.5748，Mur^-=0.4252；Lutheran血型系统基因频率：AU^a=0.8318，AU^b=0.1682；Kell、Colton，Scianna、Yt、Knops、Indian血型系统抗原基因不具有多态性，基因型分别是kk，co^aco^a，Sc1Sc1，Yt^aYt^a，Kn^aKn^a ，In^bIn^b。海南省黎族人群12个稀有血型系统基因型分布的观察值和期望值基本符合Hardy-Weinberg遗传规律， Kidd血型系统基因型的观察值与期望值比较，差别有统计学意义（χ²=17.1946，P=0.0002）. 结论: 海南省黎族人群12个红细胞血型系统稀有血型基因频率分布、遗传状况保持相对稳定，Duffy、Diego、Kidd、Drombrock、MNS、Lutheran血型系统基因呈多态性分布,与其他地区不同民族相比具有独特的分布特点；Kell、Colton、Scianna、Yt、Knops、Indian血型系统抗原基因呈单态性分布.

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