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  • Title: Once daily Theo-Dur in morning dippers.
    Author: van der Vet AP, Quaedvlieg M, Greve LH.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1988 May; 26(5):258-64. PubMed ID: 3410602.
    Abstract:
    In a group of 18 patients with a so-called "morning dip", one single dose of theophylline was administered at 10:00 p.m. by means of a sustained release formulation (Theodur Retard). The dosage of theophylline was adjusted according to the complaints of the patients. Plasma theophylline levels were determined at 10:00 a.m. to prevent theophylline intoxications. The results were objectivated by measuring the PEFR twice/day. When the optimal dosage was obtained, a once/day administration of Theodur Retard at 10:00 p.m. provided an improved peak flow in the early morning, less symptoms at night and a better quality of sleep.
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