These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Copper(II) complexes of diamino-diamido-type ligands as chiral eluents in the enantiomeric separation of D,L-dansylamino acids by reversed-phase high-performance liquid chromatography.
    Author: Armani E, Dossena A, Marchelli R, Virgili R.
    Journal: J Chromatogr; 1988 Jun 10; 441(2):275-86. PubMed ID: 3410919.
    Abstract:
    For purpose of studying the mechanism of chiral recognition in high-performance liquid chromatography (HPLC) (reversed phase), a model system is proposed, i.e., copper(II) complexes of diamino-diamido-type ligands containing L-amino acids (AA-NN-n) which added to the eluent are able to perform the enantiomeric resolution of dansylamino acids on C8 and C18 columns. Being potentially tetradentate, this system should be more liable to give an apical or outer-sphere interaction with the enantiomer rather than a simultaneous dechelation of two binding sites, as in the classical ligand-exchange mechanism. This model allows the variation of several parameters, such as the structural and electronic features of the initial complexes, their relative stabilities and lipophilicities and their correlation with enantioselectivity in HPLC.
    [Abstract] [Full Text] [Related] [New Search]